Testosterone undecanoate Injection (Nebido)

Delivery : 2 x 1000mg/4ml Vial

Substance: Testosterone undecanoate

Made by Genesis Meds.

This is probably the answer to the problems of the short life with Undecanoate capsules where you needed to take them 3 times a day. This revolutionary steroid can work in the body for 1 month if the full 4ml are taken, injected in the bum its slow release will give you the power boost for this period with no need for topping up. Or you may prefer to take 1x ml. on a weekly basis whichever way the convenience over the oral capsules is overwhelming. Also being injectable the pass through the Liver is avoided making this a cleaner, safer method of useing this steroid.

Depo-test 1000 (Test Undec Inj) (Nebido®) With Depo-Test (Nebido®) testosterone levels remain constantly - for up to 14 weeks - in the eugonadal range, avoiding unphysiological peaks and troughs. Patients value the consistent, reliable efficacy and the long duration of effect, which mean they are not dependent on taking frequent medication. Consequently, Depo-Test (Nebido®) is believed to become the standard preparation for long-term treatment.

Depo-Test (Nebido®) is injected deeply into the gluteal muscle. Following administration, testosterone undecanoate is gradually released from the depot and is cleaved by serum esterases into testosterone and undecanoic acid. An increase of serum testosterone concentrations above basal values can already be measured the very next day after injection.

DEPO Test 1000 (Schering brand name Nebido) was the first long lasting Testosterone Undecanoate Injection preparation introduced by Schering AG, Germany. They come in a 4 ml ampule per box. The 4ml contains 1,000mg (250mg per ml) of testosterone undecanoate, equivalent to 6315 mg testosterone.

One box of Nebido with the single ampule (1000mg) usually retails for around USD 300, so, that would be USD 600 for the 2 ampules you are getting with Genesis Depo-Test 1000(Nebido).

Each multi-use vial contains 1000 mg testosterone undecanoate in a 4-ml solution for injection (250 mg testosterone undecanoate/ml).

Testosterone undecanoate (TU) provides testosterone (T) replacement for hypogonadal men when administered orally but requires multiple doses per day and produces widely variable serum T levels.

We investigated the pharmacokinetics of a newly available TU preparation administered by intramuscular injection to hypogonadal men. Eight patients with Klinefelters syndrome received either 500 mg or 1,000 mg of TU by intramuscular injection; 3 months later, the other dose was given to each man (except to one, who did not receive the 1,000-mg dose). Serum levels of reproductive hormones were measured at regular intervals before and after the injections. The area under the serum T concentration-time curve and the T-distribution value related to serum T concentration were significantly higher following the 1,000-mg dose than following the 500-mg dose. The 500-mg dose, when given as the second injection, yielded optimal pharmacokinetics (defined as mean peak T values not exceeding the normal range and persistence of normal levels for at least 7 weeks), suggesting that repeated injections of 500 mg at 6-8-week intervals may provide optimal T replacement. The mean serum levels of estradiol were normalized following the injections, and prolactin levels were normal throughout the study

Significant decrease of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels was observed, with the decrease in LH levels being more pronounced. There were no significant differences in serum LH and FSH levels between the two doses. Sex hormone-binding globulin (SHBG) levels before any T therapy were near the upper limit of normal for adult men and were reduced by approximately 50% just prior to the second dose of TU. The decreased SHBG levels produced by the first TU injection could have led to lower peak total T levels and to a more rapid clearance of T following the second TU injection.

We conclude that single-dose injections of TU to hypogonadal men can maintain serum T concentration within the normal range for at least 7 weeks without immediately apparent side effects. It is likely that this form of T would require injections only at 6-8-week or longer intervals, not at the 2-week intervals necessary with currently used T esters (enanthate and cypionate). This injectable TU preparation may provide improved substitution therapy for male hypogonadism.